ARFGEF3 — ARFGEF family member 3
ARFGEF3 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ARFGEF3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Vascular EC Identity Endothelial cell development | AMOTL1, ATN1, CAMK1D, CASP10, CCNY, CFLAR, F11R, FGD5 +13 more | View in SCUBA |
| Goblet cells | Mucin O-Glycosylation Mucus production & secretion | B4GALT4, CANT1, ERGIC1, GALNT12, OS9, ROCK2, UAP1, USO1 +1 more | View in SCUBA |
About the gene
| Synonyms | BIG3, C6orf92, dJ171N11.1, KIAA1244, PPP1R33 |
|---|---|
| Chromosome | 6: 138161939-138344663 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Guanine-nucleotide releasing factor |
Function
Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.