SLFN13 — Schlafen family member 13
SLFN13 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SLFN13's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Immune regulation Immune regulation | DENND1B, FAM111A, GIT2, GOLGA8A, LPIN1, NLRC3, PPP2R5C, PSD4 +5 more | View in SCUBA |
| Gamma-delta T cells | S-phase Proliferation Cell cycle | ANKRD9, BCL6, COPS3, DCXR, ERRFI1, GMNN, GOLIM4, MTHFD2 +6 more |
About the gene
| Synonyms | FLJ31952 |
|---|---|
| Chromosome | 17: 35435096-35448837 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Endonuclease, Hydrolase, Nuclease |
Function
Endoribonuclease that cleaves tRNAs and rRNAs. Cleaves tRNAs 11 nucleotides from the 3'-terminus at the acceptor stem. Does not act on tRNA(Sec). Able to restrict HIV-1 virus replication; ability to inhibit HIV-1 replication is dependent on endoribonuclease activity
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.