ERRFI1 — ERBB receptor feedback inhibitor 1
ERRFI1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ERRFI1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | EGFR wound response Epithelial development | CLDN4, DDX60L, GPRC5A, KLF6, SNX9, STOM | View in SCUBA |
| Fibroblasts | Hypoxia Metabolic Stress Stress | ABL2, DYRK3, EMP1, HMOX1, NFATC1, PFKFB3, PIM1, SERPINE1 +3 more | View in SCUBA |
| Gamma-delta T cells | S-phase Proliferation Cell cycle | ANKRD9, BCL6, COPS3, DCXR, GMNN, GOLIM4, MTHFD2, OVCA2 +6 more | |
| Goblet cells | Stress Survival Response Stress | EPHA2, EZR, KLF6, LDLR, LMNA, MCL1, NEDD9, SQSTM1 +3 more | View in SCUBA |
| Macrophages | Hypoxia Stress Response Stress | ACE, AMPD3, APP, ASPH, BCAT1, BEX3, BHLHE41, BNIP3 +34 more | View in SCUBA |
| Monocytes | TREM1 Inflammatory Signaling Innate immunity | AGO2, AKAP12, ATP2B1, B3GNT5, BTG1, C17orf107, CHRNE, IL1R1 +6 more | View in SCUBA |
About the gene
| Synonyms | GENE-33, MIG-6, RALT |
|---|---|
| Chromosome | 1: 8004404-8026309 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.