DCXR — Dicarbonyl and L-xylulose reductase
DCXR belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DCXR's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | S-phase Proliferation Cell cycle | ANKRD9, BCL6, COPS3, ERRFI1, GMNN, GOLIM4, MTHFD2, OVCA2 +6 more | |
| Goblet cells | Electron Transport Chain Mitochondrial & OxPhos | ATP5IF1, ATP5ME, COX5B, NDUFA2, NDUFA3, NDUFB1, NDUFB10, NDUFB7 +5 more | View in SCUBA |
| Innate lymphoid cells | NK Cytotoxic Effector Cytotoxicity | ACAA2, APIP, B4GALNT1, CAMK4, CCL5, CCNG2, CD247, CD3E +17 more | View in SCUBA |
| Macrophages | Complex I / NADH Dehydrogenase Mitochondrial & OxPhos | AHCY, ANP32A, ANTKMT, APEX1, ARL2, ATIC, ATP5F1A, ATP5ME +31 more | View in SCUBA |
About the gene
| Synonyms | DCR, HCR2, KIDCR, P34H, SDR20C1 |
|---|---|
| Chromosome | 17: 82035136-82037709 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Oxidoreductase |
| Biological process | Carbohydrate metabolism, Glucose metabolism, Xylose metabolism |
Function
Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.