GMNN — Geminin DNA replication inhibitor

GMNN belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

GMNN's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Cell Cycle G1/S Cell cycle	CARHSP1, CBX5, CENPM, DNMT1, HMGB2, HMGN2, MND1, MYBL2 +8 more	View in SCUBA
CD8⁺ T cells	Replication Licensing Cell cycle	ACYP1, DDB2, DSN1, HIRIP3, ITGB3BP, LSM3, MAGOHB, NUDT1 +8 more	View in SCUBA
Gamma-delta T cells	S-phase Proliferation Cell cycle	ANKRD9, BCL6, COPS3, DCXR, ERRFI1, GOLIM4, MTHFD2, OVCA2 +6 more
Hematopoietic progenitor cells	DNA Replication S-phase Cell cycle	CDT1, CENPH, CENPK, CHEK1, E2F1, FEN1, GINS2, PCLAF +4 more
Macrophages	S-phase DNA Replication Cell cycle	ATAD2, ATAD5, BARD1, BRCA1, CENPK, CENPM, CENPU, CLSPN +31 more	View in SCUBA

About the gene

Synonyms	Gem
Chromosome	6: 24774931-24786099
Predicted location	Intracellular
Essential gene	No
Protein class	Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins
Molecular function	DNA replication inhibitor
Biological process	Cell cycle

Function

Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase- anaphase transition permits replication in the succeeding cell cycle. Inhibits histone acetyltransferase activity of KAT7/HBO1 in a CDT1-dependent manner, inhibiting histone H4 acetylation and DNA replication licensing. Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.