MTHFD2 — Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase

MTHFD2 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

MTHFD2's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Cellular biosynthesis Housekeeping	CCDC32, CTSB, HDGF, MEA1, MESD, MFSD6, MRPS11, NAA60 +9 more	View in SCUBA
CD8⁺ T cells	Glycolysis Program Housekeeping	ADRM1, CSNK2B, ENO1, NUTF2, P4HB, PGAM1, PKM, POLR2E +6 more	View in SCUBA
Endothelial	Wnt Angiogenic Remodeling ECM remodeling	ADAMTS4, ADGRL2, BAZ1A, FKBP11, IL4R, LDLRAD3, LEF1, NEURL1B +5 more	View in SCUBA
Gamma-delta T cells	S-phase Proliferation Cell cycle	ANKRD9, BCL6, COPS3, DCXR, ERRFI1, GMNN, GOLIM4, OVCA2 +6 more
Hematopoietic progenitor cells	Hematopoietic Progenitor Identity Stemness	CD38, DAD1, HSH2D, HYAL3, ITGAE, KIT, MBOAT2, PARVB +2 more
Monocytes	Inflammasome Activation Innate immunity	ATG3, CARD16, CASP1, CASP4, CD48, CD53, KYNU, PSMA4 +1 more	View in SCUBA
Pericytes	Quiescent Pericyte State Developmental	ARID5B, C1QTNF1, CPE, HOPX, ITGA7, LPP, MT2A, SLIT3 +1 more	View in SCUBA
Smooth muscle cells	Vascular SMC Identity Contractility	ADIRF, ARPC1A, BCAM, CCDC3, CRIP1, EFHD1, GPRC5C, GPX3 +10 more	View in SCUBA

About the gene

Chromosome	2: 74186172-74217565
Predicted location	Intracellular
Essential gene	No
Protein class	Enzymes, Metabolic proteins, Predicted intracellular proteins
Molecular function	Hydrolase, Multifunctional enzyme, Oxidoreductase
Biological process	One-carbon metabolism

Function

Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.