S-phase Proliferation
Gene co-expression module in Gamma-delta T cells
| Category | Cell cycle |
|---|---|
| Genes | 15 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 15 genes have a known function matching the annotation |
Why this annotation
Hub genes GMNN (canonical S/G2 cell cycle inhibitor of re-replication) and MTHFD2 (one-carbon/folate metabolism enzyme strongly and specifically upregulated in proliferating cells for nucleotide synthesis) anchor this module to cell cycle entry and S-phase. SLC1A4 transports serine, a major one-carbon donor feeding MTHFD2-mediated nucleotide synthesis. SLFN13 regulates cell growth. ERRFI1 is an EGFR-response/mitogenic signaling gene. Low detection (9.4%) is consistent with a minor cycling subpopulation of gd_T cells. The combination of a canonical cell-cycle gatekeeper (GMNN), a proliferation-specific metabolic enzyme (MTHFD2), and amino acid transport (SLC1A4) coherently defines an S-phase/proliferative metabolic program.
Genes
ANKRD9, BCL6, COPS3, DCXR, ERRFI1, GMNN, GOLIM4, MTHFD2, OVCA2, P2RY11, PARD6G, PSMD13, SC5D, SLC1A4, SLFN13
Most correlated modules
- T Cell Exhaustion · correlation 0.81
- ER Stress Response · correlation 0.79
- IRF4 T-cell Activation · correlation 0.78
- G1/S Entry · correlation 0.78
- TCR Threshold Regulation · correlation 0.78
- Activation Stress Response · correlation 0.77
- Hypoxia Tissue Adaptation · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.