SOCS2 — Suppressor of cytokine signaling 2
SOCS2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SOCS2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Lymphatic endothelial | Lymphatic Valve Identity Valve formation | ALCAM, C12orf57, C17orf58, CFH, CLDN11, DEGS2, EBPL, EDNRB +13 more | View in SCUBA |
About the gene
| Synonyms | CIS2, Cish2, SOCS-2, SSI-2, SSI2, STATI2 |
|---|---|
| Chromosome | 12: 93569814-93583487 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Signal transduction inhibitor |
| Biological process | Growth regulation, Ubl conjugation pathway |
Function
Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as EPOR and GHR. Specifically recognizes and binds phosphorylated proteins via its SH2 domain, promoting their ubiquitination. The ECS(SOCS2) complex acts as a key regulator of growth hormone receptor (GHR) levels by mediating ubiquitination and degradation of GHR, following GHR phosphorylation by JAK2. The ECS(SOCS2) also catalyzes ubiquitination and degradation of JAK2-phosphorylated EPOR.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.