Lymphatic Valve Identity
Gene co-expression module in Lymphatic endothelial
| Category | Valve formation |
|---|---|
| Genes | 22 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 20 genes have a known function matching the annotation |
Why this annotation
GJA4 (Connexin 37) is a well-established marker of lymphatic valve endothelial cells and is required for valve morphogenesis. CLDN11 (claudin-11) contributes to specialized barrier function. EDNRB (endothelin receptor B) and RAMP3 (receptor activity-modifying protein 3, part of adrenomedullin/CGRP receptor) are vasoactive signaling receptors enriched in specialized vascular/lymphatic beds. THSD1 (thrombospondin type-1 domain) is expressed in vascular endothelium. HGF (hepatocyte growth factor) promotes lymphangiogenesis. CFH (complement factor H) provides immune protection. PGRMC1 is involved in steroid signaling in endothelium. ALCAM marks specialized endothelial subsets. Together with GJA4 as a valve marker, this module most likely represents a lymphatic valve or specialized lymphatic endothelial identity program.
Genes
ALCAM, C12orf57, C17orf58, CFH, CLDN11, DEGS2, EBPL, EDNRB, GJA4, HGF, IFI27, ITM2C, LYSMD2, NAXE, PARP1, PGRMC1, PLAAT3, RAMP3, SCG3, SGCE, SOCS2, THSD1
Most correlated modules
- Endothelial Identity · correlation 0.77
- Collecting Lymphatic Identity · correlation 0.66
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.