EDNRB — Endothelin receptor type B
EDNRB belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
EDNRB's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Myofibroblast Subtype Wound healing | FOXL1, HACD4, KCTD9, MGLL, PDGFD, POSTN, TSPAN33, ZEB1 | View in SCUBA |
| Lymphatic endothelial | Lymphatic Valve Identity Valve formation | ALCAM, C12orf57, C17orf58, CFH, CLDN11, DEGS2, EBPL, GJA4 +13 more | View in SCUBA |
| Smooth muscle cells | Wnt-Hedgehog Niche Development | ADGRL3, APOC1, CLMP, CMIP, HSD17B6, IRS1, LTBP3, NPNT +8 more | View in SCUBA |
About the gene
| Synonyms | ETB, HSCR, HSCR2 |
|---|---|
| Chromosome | 13: 77895481-77975529 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, FDA approved drug targets, G-protein coupled receptors, Human disease related genes, Predicted membrane proteins |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
Function
Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.