CFH — Complement factor H
CFH belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CFH's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Lymphatic endothelial | Lymphatic Valve Identity Valve formation | ALCAM, C12orf57, C17orf58, CLDN11, DEGS2, EBPL, EDNRB, GJA4 +13 more | View in SCUBA |
| Mucosal-associated invariant T cell | Chromatin Complex Regulation DNA/chromatin regulation | APEH, CAPZB, CCND2, CHTF8, ESYT1, GDI2, HACD4, HCLS1 +9 more | |
| Pericytes | Complement Regulatory Pericyte Inflammatory | ACTN1, CD63, IGFBP7, LGALS1, MGP, SELENOM, SERPING1 | View in SCUBA |
| Smooth muscle cells | Pericyte Vasoregulatory Identity Contractility | ABCC9, ADRA2C, CCDC80, FEZ2, FGF7, KCNJ8, PCSK1N, PROS1 +6 more | View in SCUBA |
About the gene
| Synonyms | ARMD4, ARMS1, FHL1, HF, HF1, HF2, HUS |
|---|---|
| Chromosome | 1: 196651754-196752476 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Biological process | Complement alternate pathway, Host-virus interaction, Immunity, Innate immunity |
Function
Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces. Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop. As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b. In addition, mediates several cellular responses through interaction with specific receptors. For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens. In turn, these pathogens are phagocytosed and destroyed. (Microbial infection) In the mosquito midgut, binds to the surface of parasite P.falciparum gametocytes and protects the parasite from alternative complement pathway-mediated elimination
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.