SOX10 — SRY-box transcription factor 10
SOX10 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SOX10's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Glial cells | Enteric Glial Identity Development | COL8A1, DKK3, DPYSL2, NLGN4X, SCD, TENM3, WLS | View in SCUBA |
About the gene
| Synonyms | DOM, SOX-10, WS2E, WS4 |
|---|---|
| Chromosome | 22: 37970686-37987422 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding |
| Biological process | Transcription, Transcription regulation |
Function
Transcription factor that plays a central role in developing and mature glia (By similarity). Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination (By similarity). Once induced, MYRF cooperates with SOX10 to implement the myelination program (By similarity). Transcriptional activator of MITF, acting synergistically with PAX3. Transcriptional activator of MBP, via binding to the gene promoter (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.