COL8A1 — Collagen type VIII alpha 1 chain
COL8A1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
COL8A1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Inflammation-activated ECM ECM remodeling | AKR1C1, COL4A3, COL4A4, FAM107B, LIMA1, MAPKAP1, MEDAG, PTHLH +2 more | View in SCUBA |
| Glial cells | Enteric Glial Identity Development | DKK3, DPYSL2, NLGN4X, SCD, SOX10, TENM3, WLS | View in SCUBA |
About the gene
| Synonyms | C3orf7, MGC9568 |
|---|---|
| Chromosome | 3: 99638475-99799226 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted secreted proteins |
| Biological process | Angiogenesis, Cell adhesion |
Function
Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also a component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis. Vastatin, the C-terminal fragment comprising the NC1 domain, inhibits aortic endothelial cell proliferation and causes cell apoptosis
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.