Enteric Glial Identity
Gene co-expression module in Glial cells
| Category | Development |
|---|---|
| Genes | 8 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 8 genes have a known function matching the annotation |
Why this annotation
SOX10 is the master transcription factor for enteric and peripheral glia. WLS mediates Wnt ligand secretion and DKK3 modulates Wnt signaling — together defining a Wnt-active glial state. COL8A1 bridges to the neighboring collagen module (M64). TENM3, NLGN4X, and DPYSL2 are neural connectivity/axon guidance genes consistent with enteric glial support of neurons. SCD reflects lipid metabolism active in myelinating/supporting glia. Decreased in inflammation, restored in remission, consistent with a homeostatic glial identity program. Neighbor to M64 via COL8A1 shared biology.
Genes
COL8A1, DKK3, DPYSL2, NLGN4X, SCD, SOX10, TENM3, WLS
Most correlated modules
- Glial ECM Scaffold · correlation 0.90
- Collagen ECM Deposition · correlation 0.85
- Lysosomal Sphingolipid Metabolism · correlation 0.84
- Glial Homeostatic Identity · correlation 0.83
- Myelinating Schwann Cell · correlation 0.82
- Peripheral Glial Myelination · correlation 0.82
- ECM Homeostatic Regulation · correlation 0.80
- Glial Adhesion Identity · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.