DPYSL2 — Dihydropyrimidinase like 2
DPYSL2 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DPYSL2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Glucocorticoid Response Endothelial cell development | APOLD1, DENND3, JAM3, KLF11, KLF9, MFSD6, NDRG1, PHLPP1 +8 more | View in SCUBA |
| Fibroblasts | Homeostatic Fibroblast Identity ECM production | ADGRL2, C1S, DCN, DKK3, IL34, IL6ST, LUM, PARM1 +6 more | View in SCUBA |
| Glial cells | Enteric Glial Identity Development | COL8A1, DKK3, NLGN4X, SCD, SOX10, TENM3, WLS | View in SCUBA |
| Lymphatic endothelial | Glycolytic Housekeeping Housekeeping | CALCOCO2, CANX, CAP1, DYNC1I2, EIF2S2, ENO1, GIMAP8, PGAM1 +1 more | View in SCUBA |
| Macrophages | Innate Antiviral Sensing Innate immunity | ADA2, ADPRH, ALDH9A1, APOBEC3C, BST2, C2, CAT, CD4 +26 more | View in SCUBA |
| Pericytes | Actin Cytoskeletal Remodeling Cytoskeletal | CDC42EP1, ETS1, FMNL3, HDAC1, LXN, ORAI2, RAI14, SHC1 | View in SCUBA |
About the gene
| Synonyms | CRMP2, DHPRP2, DRP-2, DRP2 |
|---|---|
| Chromosome | 8: 26514031-26658178 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Developmental protein |
| Biological process | Differentiation, Neurogenesis |
Function
Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.