SCD — Stearoyl-CoA desaturase
SCD belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SCD's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Glial cells | Enteric Glial Identity Development | COL8A1, DKK3, DPYSL2, NLGN4X, SOX10, TENM3, WLS | View in SCUBA |
| Macrophages | Oxidative Metabolic Program Mitochondrial & OxPhos | ACADM, CA2, CALM3, CAPG, COQ2, CSRP1, CSTB, DENND2D +29 more | View in SCUBA |
About the gene
| Synonyms | FADS5, SCD1, SCDOS |
|---|---|
| Chromosome | 10: 100347233-100364826 |
| Predicted location | Membrane |
| Essential gene | Yes |
| Protein class | Enzymes, Essential proteins, Metabolic proteins, Predicted membrane proteins |
| Molecular function | Oxidoreductase |
| Biological process | Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism |
Function
Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity). Plays an important role in body energy homeostasis (By similarity). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.