WLS — Wnt ligand secretion mediator
WLS belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
WLS's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Quiescent EC Identity Endothelial cell development | ADRB1, CAMK2D, CLU, CYP1B1, FAM20A, FOXP1, FZD6, GCHFR +19 more | View in SCUBA |
| Fibroblasts | Actin Cytoskeletal Organization Cytoskeletal | ACP1, AKR7A2, ARL3, CAPZB, DERL1, GDE1, LEPROTL1, LIMS1 +8 more | View in SCUBA |
| Glial cells | Enteric Glial Identity Development | COL8A1, DKK3, DPYSL2, NLGN4X, SCD, SOX10, TENM3 | View in SCUBA |
| Lymphatic endothelial | Collecting Lymphatic Identity migration & adhesion | CCDC141, EFNB2, EPB41, FBXO34, FGD6, GUCY1A1, ITGA6, MDFIC +13 more | View in SCUBA |
| Macrophages | Myeloid Signaling Regulation Innate immunity | ADGRG6, AOAH, CCDC170, CD302, CMKLR1, CPED1, DIPK2A, FAM13A +38 more | View in SCUBA |
| Neutrophils | Degranulation Trafficking Degranulation | ATP11A, BIN2, CSGALNACT2, FRY, KDM7A, LPGAT1, PYGL, RAB27A +7 more | |
| Smooth muscle cells | Collagen-Laminin Deposition ECM remodeling | COL5A1, COL5A2, COL6A3, LAMA4, LAMB1, NEGR1, PARVA, PCDH7 +4 more | View in SCUBA |
About the gene
| Synonyms | C1orf139, EVI, FLJ23091, GPR177, mig-14, MRP |
|---|---|
| Chromosome | 1: 68098473-68233120 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | Developmental protein |
| Biological process | Wnt signaling pathway |
Function
Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.