TBXA2R — Thromboxane A2 receptor
TBXA2R belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TBXA2R's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Angiogenic Endothelial Identity Endothelial cell development | ADAMTSL2, ARHGAP29, COL13A1, CTNNB1, EDIL3, EML1, ETS1, EXOC3L1 +14 more | View in SCUBA |
About the gene
| Chromosome | 19: 3594507-3606875 |
|---|---|
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, G-protein coupled receptors, Human disease related genes, Predicted membrane proteins |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
Function
Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G- protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Activates adenylyl cyclase. Inhibits adenylyl cyclase
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.