ETS1 — ETS proto-oncogene 1, transcription factor

ETS1 belongs to a gene co-expression module in 11 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

ETS1's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	B-cell activation signaling B cell maturation	CD180, CYB561A3, DAAM1, LIMD2, STX7, TERF2IP, UCP2, ZNF106	View in SCUBA
CD4⁺ T cells	T Cell Signaling B cell help	CCDC6, EFNB2, ELMO1, MYO5A, PTPN11, RABGAP1L, SFXN1, SH2D1A +4 more	View in SCUBA
CD8⁺ T cells	CD8 Effector Maturation T cell maturation	AKAP13, ATXN1, CD81, DDX17, DDX3X, IKZF3, JUND, MXD4 +8 more	View in SCUBA
Endothelial	Angiogenic Endothelial Identity Endothelial cell development	ADAMTSL2, ARHGAP29, COL13A1, CTNNB1, EDIL3, EML1, EXOC3L1, FHOD1 +14 more	View in SCUBA
Fibroblasts	Wnt-BMP Fibroblast Developmental	ABCC4, BMP7, EMID1, GJA1, GNG2, LEF1, MFGE8, PAPLN +5 more	View in SCUBA
Gamma-delta T cells	T cell Identity Signaling TCR Signaling	CDC42SE1, CLIP4, FCHSD1, H3C1, ITGA4, ITK, KHNYN, MARCHF6 +14 more
Hematopoietic progenitor cells	Glucocorticoid Response Inflammatory	ARL4C, CYTH1, EMP1, FOS, KLF6, LRRFIP1, PDE4B, PTPRC +4 more
Innate lymphoid cells	AP-1 Transcriptional Activation DNA regulation & transcription	AHNAK, ALYREF, CD81, CDV3, CITED4, ESYT2, GNAI2, GRK2 +28 more	View in SCUBA
Mucosal-associated invariant T cell	T cell Transcriptional Identity T cell maturation	AAK1, ANKRD36B, ATG16L2, BCL11B, EMB, GOLGA8B, HNRNPUL2, LSM14A +8 more
Natural Killer cells	NK Cell Identity Differentiation	APBA2, APMAP, COLQ, FCMR, FKBP11, GSAP, ICAM2, MRPL10 +2 more	View in SCUBA
Pericytes	Actin Cytoskeletal Remodeling Cytoskeletal	CDC42EP1, DPYSL2, FMNL3, HDAC1, LXN, ORAI2, RAI14, SHC1	View in SCUBA

About the gene

Synonyms	ETS-1, EWSR2, FLJ10768
Chromosome	11: 128458761-128587558
Predicted location	Intracellular
Essential gene	No
Protein class	Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins, Transcription factors
Molecular function	DNA-binding
Biological process	Immunity, Transcription, Transcription regulation

Function

Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion. Acts as a dominant-negative for isoform c-ETS-1A

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.