Angiogenic Endothelial Identity
Gene co-expression module in Endothelial
| Category | Endothelial cell development |
|---|---|
| Genes | 23 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 23 genes have a known function matching the annotation |
Why this annotation
KDR (VEGFR2) is the canonical VEGF receptor and master regulator of endothelial identity and angiogenesis. ARHGAP29 regulates Rho GTPase activity downstream of VEGFR2 in vascular morphogenesis. PLPP3 (lipid phosphatase 3) modulates S1P/LPA signaling in angiogenesis. CTNNB1 (β-catenin) mediates Wnt signaling critical for vascular development. ETS1 is a key transcription factor for endothelial gene programs. NOVA2 is an endothelial splicing regulator controlling vascular morphogenesis. EDIL3 is an integrin ligand promoting angiogenesis. ADAMTSL2 and COL13A1 support ECM remodeling during vessel formation. TMEM204 is endothelial-enriched. The module is upregulated in UC inflammation, consistent with angiogenic activation. As a neighbor to M33 (arterial identity), this module likely represents the broader angiogenic/pan-endothelial program.
Genes
ADAMTSL2, ARHGAP29, COL13A1, CTNNB1, EDIL3, EML1, ETS1, EXOC3L1, FHOD1, GNG11, GRB10, HECW2, KDR, MLEC, NOVA2, PLPP3, RAPGEF4, TBXA2R, TM4SF18, TMEM150C, TMEM204, UNC119B, VAMP5
Most correlated modules
- Basement Membrane Assembly · correlation 0.83
- Mitophagy Stress Response · correlation 0.82
- Actomyosin Contractility · correlation 0.81
- Venous Endothelial Identity · correlation 0.81
- Venous Endothelial Identity · correlation 0.79
- Endothelial Lipid Signaling · correlation 0.78
- Arterial EC Identity · correlation 0.77
- VEGF Tip Cell Signaling · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.