ARHGAP29 — Rho GTPase activating protein 29
ARHGAP29 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ARHGAP29's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Angiogenic Endothelial Identity Endothelial cell development | ADAMTSL2, COL13A1, CTNNB1, EDIL3, EML1, ETS1, EXOC3L1, FHOD1 +14 more | View in SCUBA |
| Fibroblasts | PI16+ Fibroblast Identity ECM production | AADACL2, ADAMTSL4, C16orf89, CADM3, CD248, CLEC3B, CYP4B1, F10 +10 more | View in SCUBA |
| Lymphatic endothelial | Lymphatic Specification endothelial development | BOD1L1, CALD1, CLCN3, DECR1, GCC2, MINDY2, MPHOSPH8, MTUS1 +9 more | View in SCUBA |
| Pericytes | Pericyte Vascular Identity Developmental | AHR, CA4, CD46, MEF2C, MYO6, NOTCH1, PDE1C, PLXND1 +10 more | View in SCUBA |
| Smooth muscle cells | Vasoconstrictor Signaling Contractility | ATP10A, BBX, CDK18, CSRP2, EDNRA, GPAT2, NR3C1, NUDT4 +4 more | View in SCUBA |
About the gene
| Synonyms | PARG1 |
|---|---|
| Chromosome | 1: 94148988-94275068 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | GTPase activation |
Function
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.