TMEM119 — Transmembrane protein 119
TMEM119 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TMEM119's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Caveolae Mechanosensing Cytoskeletal | APLP2, ARHGAP18, BDKRB2, CACNA1H, CAV1, CAV2, CD9, CPED1 +10 more | View in SCUBA |
About the gene
| Synonyms | OBIF |
|---|---|
| Chromosome | 12: 108589851-108598320 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Biological process | Biomineralization, Differentiation, Osteogenesis, Spermatogenesis |
Function
Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts. May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Up- regulates the expression of ATF4, a transcription factor which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.