CACNA1H — Calcium voltage-gated channel subunit alpha1 H
CACNA1H belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CACNA1H's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Caveolae Mechanosensing Cytoskeletal | APLP2, ARHGAP18, BDKRB2, CAV1, CAV2, CD9, CPED1, DMD +10 more | View in SCUBA |
| Smooth muscle cells | Lipid Kinase Signaling Housekeeping | ABTB1, ARRDC4, CBX7, CX3CL1, DGKD, DNTTIP2, FCHSD2, FYTTD1 +10 more | View in SCUBA |
About the gene
| Synonyms | Cav3.2 |
|---|---|
| Chromosome | 16: 1153106-1221771 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, FDA approved drug targets, Human disease related genes, Predicted membrane proteins, Transporters, Voltage-gated ion channels |
| Molecular function | Calcium channel, Ion channel, Voltage-gated channel |
| Biological process | Calcium transport, Ion transport, Transport |
Function
Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle (Probable). They may also be involved in the modulation of firing patterns of neurons. In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.