CAV1 — Caveolin 1
CAV1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CAV1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | CD200 immunoregulation Immune regulation | B3GNT2, CD200, CD79A, CH25H, CHGB, DUOX1, ELF2, EVI5 +23 more | View in SCUBA |
| Endothelial | Caveolae-mediated Transcytosis Metabolite transfer | ADIPOR2, CAV2, CCDC85A, CD320, EEPD1, EMP2, ENAH, HIF3A +19 more | View in SCUBA |
| Fibroblasts | Caveolae Mechanosensing Cytoskeletal | APLP2, ARHGAP18, BDKRB2, CACNA1H, CAV2, CD9, CPED1, DMD +10 more | View in SCUBA |
| Pericytes | Caveolae Organization Cytoskeletal | CAV2, CAVIN1, PDLIM5, PLEC, PLS3, SYNE2, UTRN | View in SCUBA |
| Smooth muscle cells | SMC contractile apparatus Contractility | ACTA2, ACTB, CALD1, DSTN, MYL6, MYL9, PPP1R14A, SH3BGRL +2 more | View in SCUBA |
About the gene
| Synonyms | CAV |
|---|---|
| Chromosome | 7: 116524994-116561179 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Biological process | Host-virus interaction |
Function
May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation. Binds 20(S)- hydroxycholesterol (20(S)-OHC) (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.