Caveolae Mechanosensing
Gene co-expression module in Fibroblasts
| Category | Cytoskeletal |
|---|---|
| Genes | 19 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 19 genes have a known function matching the annotation |
Why this annotation
CAV1 and CAV2 encode caveolin-1 and -2, structural proteins of caveolae that mediate mechanosensing and lipid raft signaling in fibroblasts. PDGFC is a PDGF ligand. ITGA1 (integrin alpha-1) mediates cell-matrix adhesion. PALLD (palladin) is an actin-associated cytoskeletal protein important in fibroblast morphology. CD9 (tetraspanin) and DMD (dystrophin) support a mechanosensing/cytoskeletal scaffold program. ARHGAP18 is a Rho-GAP involved in cytoskeletal regulation. This module represents a caveolae-mediated mechanosensing and cytoskeletal organization program in intestinal fibroblasts.
Genes
APLP2, ARHGAP18, BDKRB2, CACNA1H, CAV1, CAV2, CD9, CPED1, DMD, GNA13, GPR20, ITGA1, MINDY2, OLFML2A, PALLD, PBXIP1, PDGFC, RYBP, TMEM119
Most correlated modules
- Myofibroblast Subtype · correlation 0.90
- Telocyte Identity Program · correlation 0.90
- Metabolic Homeostasis · correlation 0.84
- Actin Cytoskeletal Organization · correlation 0.82
- WNT-modulating Fibroblast · correlation 0.80
- Lysosomal Cytoskeletal · correlation 0.80
- Fibroblast Niche Identity · correlation 0.79
- ECM Glycan Remodeling · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.