CAV2 — Caveolin 2
CAV2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CAV2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Caveolae-mediated Transcytosis Metabolite transfer | ADIPOR2, CAV1, CCDC85A, CD320, EEPD1, EMP2, ENAH, HIF3A +19 more | View in SCUBA |
| Fibroblasts | Caveolae Mechanosensing Cytoskeletal | APLP2, ARHGAP18, BDKRB2, CACNA1H, CAV1, CD9, CPED1, DMD +10 more | View in SCUBA |
| Pericytes | Caveolae Organization Cytoskeletal | CAV1, CAVIN1, PDLIM5, PLEC, PLS3, SYNE2, UTRN | View in SCUBA |
| Smooth muscle cells | Oxidative Muscle Metabolism Mitochondrial & OxPhos | COX7A1, CRIP2, FXYD1, HCFC1R1, LGR6, MFGE8, MGST3, NDUFB7 +2 more | View in SCUBA |
About the gene
| Synonyms | CAV |
|---|---|
| Chromosome | 7: 116287380-116508541 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins |
Function
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.