TMEM39A — Transmembrane protein 39A
TMEM39A belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TMEM39A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | NK-like Mature gd-T cytotoxicity | ABHD2, ATG9A, CEP78, HAVCR2, HSH2D, IFIT2, ITGAX, KIR2DL1 +14 more |
About the gene
| Synonyms | FLJ10902, SUSR2 |
|---|---|
| Chromosome | 3: 119428949-119468830 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins, Transporters |
| Biological process | Autophagy |
Function
Regulates autophagy by controlling the spatial distribution and levels of the intracellular phosphatidylinositol 4-phosphate (PtdIns(4)P) pools. Modulates (PtdIns(4)P) levels by regulating the ER-to-Golgi trafficking of the phosphatidylinositide phosphatase SACM1L. (Microbial infection) Positively regulates the replication of encephalomyocarditis virus (EMCV) via autophagy-dependent pathway
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.