CEP78 — Centrosomal protein 78
CEP78 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CEP78's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | NK-like Mature gd-T cytotoxicity | ABHD2, ATG9A, HAVCR2, HSH2D, IFIT2, ITGAX, KIR2DL1, KIR2DL3 +14 more | |
| Macrophages | Centrosome & DNA Repair Cell cycle | ANKRD13A, BRCA2, CASP2, CBX5, CCDC14, CEP152, CKAP5, CSE1L +34 more | View in SCUBA |
| Natural Killer cells | NK Activation Signaling activation | PLSCR3, PSAP, RASA3, SLC44A2, SUN2, ZAP70, ZYX | View in SCUBA |
About the gene
| Synonyms | C9orf81, FLJ12643 |
|---|---|
| Chromosome | 9: 78236062-78279690 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Biological process | Cilium biogenesis/degradation |
Function
Centriole wall protein that localizes to mature centrioles and regulates centriole and cilia biogenesis. Involved in centrosome duplication: required for efficient PLK4 centrosomal localization and PLK4-induced overduplication of centrioles. Involved in cilium biogenesis and controls cilium length. Acts as a regulator of protein stability by preventing ubiquitination of centrosomal proteins, such as CCP110 and tektins. Associates with the EDVP complex, preventing ubiquitination and degradation of CCP110. Promotes deubiquitination of tektin proteins (TEKT1, TEKT2, TEK3, TEKT4 and TEKT5) via its interaction with USP16 (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.