HSH2D — Hematopoietic SH2 domain containing
HSH2D belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HSH2D's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | BCR Ras signaling BCR/AP1/NFKb pathway | ANKRD28, CCL5, DOK3, GSTK1, GYPC, HOPX, ITGAM, MCOLN2 +12 more | View in SCUBA |
| CD4⁺ T cells | Leukocyte Motility migration & adhesion | ATP2A3, LRP12, LZTFL1, MYO1G, MYO9B, NBEAL2, PPARG, TBC1D31 +1 more | View in SCUBA |
| Gamma-delta T cells | NK-like Mature gd-T cytotoxicity | ABHD2, ATG9A, CEP78, HAVCR2, IFIT2, ITGAX, KIR2DL1, KIR2DL3 +14 more | |
| Hematopoietic progenitor cells | Hematopoietic Progenitor Identity Stemness | CD38, DAD1, HYAL3, ITGAE, KIT, MBOAT2, MTHFD2, PARVB +2 more | |
| Innate lymphoid cells | Actin Cytoskeleton Dynamics Cytoskeleton & motility | ACTN4, ALDH9A1, APBB1IP, ARHGAP10, CDC37, CXXC5, FAM136A, FERMT3 +26 more | View in SCUBA |
About the gene
| Synonyms | ALX, FLJ14886, HSH2 |
|---|---|
| Chromosome | 19: 16134028-16158575 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
May be a modulator of the apoptotic response through its ability to affect mitochondrial stability (By similarity). Adapter protein involved in tyrosine kinase and CD28 signaling. Seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 promoter.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.