NK-like Mature gd-T
Gene co-expression module in Gamma-delta T cells
| Category | cytotoxicity |
|---|---|
| Genes | 23 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 14 of 23 genes have a known function matching the annotation |
Why this annotation
Hub genes are dominated by multiple KIR receptors (KIR2DL1, KIR2DL3, KIR3DL1, KIR3DL2) alongside NCR1 (NKp46), NCAM1 (CD56), and HAVCR2 (TIM-3). This combination defines a terminally differentiated NK-like γδ T cell state with acquired KIR expression. Supporting members include ITGAX (CD11c, expressed on cytotoxic lymphocytes), LYN and HSH2D (lymphocyte signaling), autophagy/lysosomal genes (RUBCN, MCOLN2, ATG9A) consistent with cytotoxic granule biology, and ABHD2 (reported on mature γδ T cells). TERF1 suggests telomere maintenance in mature/long-lived cells. IFIT2 may reflect tonic IFN signaling in this subset. The module fits a KIR+ NK-like mature cytotoxic γδ T cell program, situated in a neighborhood of other cytotoxic effector modules (M17, M125).
Genes
ABHD2, ATG9A, CEP78, HAVCR2, HSH2D, IFIT2, ITGAX, KIR2DL1, KIR2DL3, KIR3DL1, KIR3DL2, LMBR1L, LYN, MCOLN2, NCAM1, NCR1, RFTN1, RRN3, RUBCN, SETBP1, TERF1, TMEM39A, TOGARAM2
Most correlated modules
- Effector Cytokine Secretion · correlation 0.80
- cAMP Lipid Signaling · correlation 0.74
- XCL1/XCL2 Cytotoxic Activation · correlation 0.61
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.