TPSAB1 — Tryptase alpha/beta 1
TPSAB1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TPSAB1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Hematopoietic progenitor cells | Mast Cell Differentiation Granulocyte development | ACSL4, ALOX5AP, BACE2, CDK15, CNKSR3, FAM81B, FAM83F, FOXJ1 +6 more |
About the gene
| Synonyms | TPS1, TPS2, TPSB1 |
|---|---|
| Chromosome | 16: 1240379-1242554 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted secreted proteins |
| Molecular function | Hydrolase, Protease, Serine protease |
Function
Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.