TRIM58 — Tripartite motif containing 58
TRIM58 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TRIM58's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Hematopoietic progenitor cells | Erythroid Maturation Signaling Erythropoietic | ATP1B1, ELMO1, GUCY1B1, HTR1F, IGSF10, MED12L, PLXDC2, PRKACB +3 more |
About the gene
| Synonyms | BIA2 |
|---|---|
| Chromosome | 1: 247857187-247880138 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Transferase |
| Biological process | Ubl conjugation pathway |
Function
E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. May participate in the erythroblast enucleation process through regulation of nuclear polarization
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.