TRIP6 — Thyroid hormone receptor interactor 6
TRIP6 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TRIP6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Actomyosin Contractility Cytoskeletal | BCL7C, BLCAP, C20orf204, CMBL, CTDSPL, DDB2, FLRT2, ITM2C +11 more | View in SCUBA |
About the gene
| Synonyms | MGC10556, MGC10558, MGC29959, MGC3837, MGC4423, OIP1, ZRP-1 |
|---|---|
| Chromosome | 7: 100867387-100873454 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Cell adhesion, Transcription, Transcription regulation |
Function
Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF- kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.