CTDSPL — CTD small phosphatase like
CTDSPL belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CTDSPL's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Actomyosin Contractility Cytoskeletal | BCL7C, BLCAP, C20orf204, CMBL, DDB2, FLRT2, ITM2C, KLHL4 +11 more | View in SCUBA |
| Smooth muscle cells | Costameric cytoskeleton Cytoskeletal | ACTR2, AOC3, APLP2, FLNC, GNG11, HSPG2, KANK2, NFIA +4 more | View in SCUBA |
About the gene
| Synonyms | C3orf8, HYA22, PSR1, RBSP3, SCP3 |
|---|---|
| Chromosome | 3: 37861880-37984469 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase, Protein phosphatase |
Function
Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.