Actomyosin Contractility
Gene co-expression module in Endothelial
| Category | Cytoskeletal |
|---|---|
| Genes | 20 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes MYL6B (non-muscle myosin light chain, actomyosin contractility), TRIP6 (LIM domain focal adhesion scaffold, mechanosensing), P2RX4 (purinergic receptor, mechanosensitive ion channel in ECs), MPST (mercaptopyruvate sulfurtransferase, H2S metabolism), ITM2C (integral membrane protein), BLCAP (bladder cancer-associated protein, growth suppressor), DDB2 (DNA damage binding), NDUFS7 (mitochondrial complex I subunit). The module is a mixed program combining actomyosin/focal adhesion (MYL6B, TRIP6) with metabolic and stress-response elements. The dominant cytoskeletal theme and upregulation in CD inflammation suggest EC mechanoadaptation or remodeling.
Genes
BCL7C, BLCAP, C20orf204, CMBL, CTDSPL, DDB2, FLRT2, ITM2C, KLHL4, MPP1, MPST, MYL6B, NDUFS7, NTAN1, P2RX4, PLEKHA4, PXMP2, SCARA3, TRIP6, TSPAN11
Most correlated modules
- Venous EC Identity · correlation 0.95
- Inflammatory ECM Remodeling · correlation 0.87
- Arterial EC Identity · correlation 0.81
- EC Cytoskeletal Scaffold · correlation 0.77
- NF-κB Stress Signaling · correlation 0.76
- Inflammatory Angiogenesis · correlation 0.72
- Inflammatory Stress Response · correlation 0.71
- Venous EC Identity · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.