TUBB3 — Tubulin beta 3 class III
TUBB3 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TUBB3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Monocytes | Immediate Early Activation Stress | ARRDC2, GALR2, IER5L, MRPL55, MTSS1, NDUFA12, NXT1, RRAS +3 more | View in SCUBA |
About the gene
| Synonyms | beta-4, CFEOM3, CFEOM3A, FEOM3 |
|---|---|
| Chromosome | 16: 89921392-89938761 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
Function
Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, alpha-beta tubulin heterodimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. TUBB3 plays a critical role in proper axon guidance and maintenance. Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Plays a role in dorsal root ganglion axon projection towards the spinal cord.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.