RRAS — RAS related
RRAS belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RRAS's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Vascular Homeostasis Endothelial cell development | ATP2A3, ATP6V1C2, C19orf33, CP, EMP3, ICAM2, MERTK, PLLP +5 more | View in SCUBA |
| Macrophages | NF-κB Inflammatory Activation Inflammatory | ADM, CCL2, CCL20, CCL7, CLEC4E, CXCL1, CXCL2, CXCL3 +19 more | View in SCUBA |
| Monocytes | Immediate Early Activation Stress | ARRDC2, GALR2, IER5L, MRPL55, MTSS1, NDUFA12, NXT1, SLC7A7 +3 more | View in SCUBA |
| Smooth muscle cells | Calcium Handling Contractility | ASAP2, DDX24, MYCBP2, NBDY, PDE1A, RBM24, RNF180, RYR2 +3 more | View in SCUBA |
About the gene
| Synonyms | R-Ras |
|---|---|
| Chromosome | 19: 49635292-49640143 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, RAS pathway related proteins |
| Molecular function | Hydrolase |
Function
GTP-binding protein with GTPase activity, likely involved in the regulation of MAPK signaling pathway and thereby controlling multiple cellular processes. Regulates the organization of the actin cytoskeleton. With OSPBL3, modulates integrin beta-1 (ITGB1) activity.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.