SCUBA

NDUFA12 — NADH:ubiquinone oxidoreductase subunit A12

NDUFA12 belongs to a gene co-expression module in 11 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

NDUFA12's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsOxidative Phosphorylation
Mitochondrial & OxPhos
ATP5MC3, ATP5MF, ATP5PB, ATP5PF, COX5A, ELOB, ERH, LDHB +8 moreView in SCUBA
CD8⁺ T cellsComplex I / OXPHOS
Mitochondrial & OxPhos
DAD1, GSTO1, GTF3C6, MANF, NDUFA4, NDUFAB1, NDUFB3, NDUFS6 +1 moreView in SCUBA
EndothelialIL-27 Receptor Signaling
Inflammation
CCND3, CDC37, HOXB2, IL27RA, KL, MMP15, SPARCL1, TMEM243View in SCUBA
FibroblastsMitochondrial OxPhos
Mitochondrial & OxPhos
ATP5PF, COX6A1, COX6C, GSTP1, MGST3, NDUFA8, NDUFB10, NDUFB4 +6 moreView in SCUBA
Gamma-delta T cellsCytotoxic Effector Actin
cytotoxicity
ARPC2, ARPC5, ATOX1, BRK1, CFL1, CLIC1, CORO1A, DBI +14 more
Goblet cellsMitochondrial OxPhos
Mitochondrial & OxPhos
ATP5MC1, ATP5MC3, ATP5PF, DBI, MTCH2, NDUFB2, TPI1View in SCUBA
Lymphatic endothelialMitochondrial OxPhos Complex
Mitochondrial & OxPhos
ANAPC11, AP2M1, BRK1, LSM3, MRPL51, MRPS21, NDUFAB1, NDUFB2 +6 moreView in SCUBA
MacrophagesMitochondrial OXPHOS
Mitochondrial & OxPhos
ATP5IF1, ATP5MC2, ECH1, FAM89B, GMFG, GSTP1, HIGD2A, LAMTOR4 +9 moreView in SCUBA
MonocytesImmediate Early Activation
Stress
ARRDC2, GALR2, IER5L, MRPL55, MTSS1, NXT1, RRAS, SLC7A7 +3 moreView in SCUBA
Mucosal-associated invariant T cellCytotoxic Lymphocyte Program
cytotoxicity
ANXA11, CDKN2D, CYB5A, EMP3, ETHE1, FLT3LG, GLIPR2, LDHB +9 more
PericytesG1 Cell Cycle Entry
Cell cycle
CCND3, CCNY, CPNE8, FKBP9, GRAMD1A, LIPA, MAPK3, MGAT1 +6 moreView in SCUBA

About the gene

SynonymsB17.2, DAP13
Chromosome12: 94895297-95003748
Predicted locationIntracellular
Essential geneNo
Protein classDisease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins
Biological processElectron transport, Respiratory chain, Transport

Function

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.