U2AF1 — U2 small nuclear RNA auxiliary factor 1
U2AF1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
U2AF1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | RNA Splicing Nuclear RNA processing & translation | ATRAID, BABAM2, C7orf50, CIB1, CSNK2A1, FUNDC2, GOLGA8A, GOLGA8B +10 more | |
| Macrophages | Antimicrobial Oxidative Defense Antibacterial | ADAMDEC1, ALDOA, APOL3, CALHM6, CLEC10A, COX16, CPVL, DEFA5 +30 more | View in SCUBA |
| Monocytes | Inflammatory Monocyte Activation Inflammatory | ALDOA, C11orf98, CLEC2B, CNIH4, CRIP1, GRINA, IFITM2, LEPROTL1 +5 more | View in SCUBA |
About the gene
| Synonyms | RN, RNU2AF1, U2AF35, U2AFBP |
|---|---|
| Chromosome | 21: 43092956-43107570 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Cancer-related genes, Disease related genes, Essential proteins, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | RNA-binding |
| Biological process | mRNA processing, mRNA splicing |
Function
Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.