UBE4B — Ubiquitination factor E4B
UBE4B belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
UBE4B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Post-transcriptional Regulation Housekeeping | AKAP10, ATF7IP, ATRN, ATXN2, BAZ2B, BLTP1, BRWD1, CELF2 +34 more | View in SCUBA |
About the gene
| Synonyms | E4, KIAA0684, UBOX3, UFD2 |
|---|---|
| Chromosome | 1: 10032832-10181239 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Transferase |
| Biological process | Ubl conjugation pathway |
Function
Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases (By similarity). May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase (By similarity). May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.