UQCC3 — Ubiquinol-cytochrome c reductase complex assembly factor 3
UQCC3 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
UQCC3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Glycosylation & trafficking Protein processing & ER | AASDHPPT, ABHD12, ACTR1A, ANKRD35, AP1S1, ARRDC1, ATF6B, ATG5 +25 more | View in SCUBA |
About the gene
| Synonyms | C11orf83, UNQ655 |
|---|---|
| Chromosome | 11: 62670273-62673686 |
| Predicted location | Membrane |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Human disease related genes, Predicted membrane proteins |
| Biological process | ATP synthesis |
Function
Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin-binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.