Glycosylation & trafficking
Gene co-expression module in CD4⁺ T cells
| Category | Protein processing & ER |
|---|---|
| Genes | 34 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 34 genes have a known function matching the annotation |
Why this annotation
Hub genes are broadly metabolic/housekeeping: glycosylation (FUT8, ST6GALNAC4), ER/Golgi trafficking (ATF6B, RAB1B, AP1S1, DNAJC5), mitochondrial (LETM1, CYB5B, UQCC3), autophagy (ATG5). No coherent immune program; this is a general cellular metabolism/protein processing module with uniform low expression upregulated in inflammation, likely reflecting general metabolic activation. Mixed but leans toward protein processing/secretory machinery.
Genes
AASDHPPT, ABHD12, ACTR1A, ANKRD35, AP1S1, ARRDC1, ATF6B, ATG5, CDK19, CNDP2, COA5, CXorf38, CYB5B, DCAF7, DNAJC5, FUT8, HGS, KCNAB2, LBR, LETM1, MCRS1, RAB1B, RIN3, RNASEH1, SECISBP2L, SMARCD2, SOCS4, ST6GALNAC4, TBC1D20, THEMIS2, TMEM33, TOR1A, UQCC3, ZCCHC2
Most correlated modules
- PD-L1 checkpoint · correlation 0.97
- Oxidative phosphorylation · correlation 0.94
- Activated Effector ISG · correlation 0.93
- Respiratory chain assembly · correlation 0.90
- Mixed Metabolic Ambient · correlation 0.84
- Epigenetic regulation · correlation 0.84
- Vesicular trafficking · correlation 0.80
- Chromatin regulation · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.