ABHD12 — Abhydrolase domain containing 12, lysophospholipase
ABHD12 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ABHD12's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Glycosylation & trafficking Protein processing & ER | AASDHPPT, ACTR1A, ANKRD35, AP1S1, ARRDC1, ATF6B, ATG5, CDK19 +25 more | View in SCUBA |
| Enterocytes | Brush border lipid handling Absorption | ABCG1, ARL14, CDHR2, ENTPD8, IDS, PNPLA2, RAI14, SEMA3G +2 more | View in SCUBA |
| Gamma-delta T cells | TGF-beta Signaling Immune regulation | ABCF1, ACAP2, ADIPOR2, CBX6, ENPP4, FBXO9, GSAP, INPP4A +18 more | |
| Macrophages | Efferocytosis Anti-inflammatory Lysosomal & pahgocytosis | ADGRG5, AIG1, AXL, CCS, CD101, CD1D, CD300A, EVA1B +18 more | View in SCUBA |
About the gene
| Synonyms | ABHD12A, BEM46L2, C20orf22, dJ965G21.2, DKFZP434P106 |
|---|---|
| Chromosome | 20: 25294742-25390835 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Hydrolase |
| Biological process | Lipid metabolism |
Function
Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes. Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system (By similarity). Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal. Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways. Has a strong preference for very-long-chain lipid substrates; substrate specificity is likely due to improved catalysis and not improved substrate binding.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.