VDR — Vitamin D receptor
VDR belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
VDR's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Epigenetic regulation DNA/chromatin regulation | AFF4, ARID1B, CTSA, DGKH, FUBP1, JARID2, PDCD6, SYNCRIP +6 more | View in SCUBA |
| Macrophages | Osmotic Stress Response Stress | ANKRD28, BZW1, CD109, CXCL8, CYB5R4, CYTIP, DUSP4, EMP3 +25 more | View in SCUBA |
| Monocytes | Monocyte Immune Tolerance Tissue adaptation | ATP1B3, CTSL, EMP1, FCER1G, FTH1, HAVCR2, INSIG1, MALT1 +1 more | View in SCUBA |
About the gene
| Synonyms | NR1I1, PPP1R163 |
|---|---|
| Chromosome | 12: 47841537-47943048 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, FDA approved drug targets, Human disease related genes, Nuclear receptors, Predicted intracellular proteins, Transcription factors, Transporters |
| Molecular function | DNA-binding, Receptor |
| Biological process | Transcription, Transcription regulation |
Function
Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes. Plays a central role in calcium homeostasis (By similarity). Also functions as a receptor for the secondary bile acid lithocholic acid (LCA) and its metabolites.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.