XYLT1 — Xylosyltransferase 1
XYLT1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
XYLT1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | PI3K Lipid Signaling Innate immunity | AGPAT4, AREG, DHX34, DNMBP, EEPD1, HIP1, IP6K1, IRAK2 +23 more | View in SCUBA |
About the gene
| Synonyms | PXYLT1, XT-I |
|---|---|
| Chromosome | 16: 17101769-17470960 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Glycosyltransferase, Transferase |
Function
Catalyzes the first step in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans, such as DCN. Transfers D- xylose from UDP-D-xylose to specific serine residues of the core protein. Required for normal embryonic and postnatal skeleton development, especially of the long bones. Required for normal maturation of chondrocytes during bone development, and normal onset of ossification (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.