ZWILCH — Zwilch kinetochore protein
ZWILCH belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ZWILCH's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Mitochondrial Metabolism Mitochondrial & OxPhos | CYC1, ELAVL1, HINT2, PRDX3, RNPS1, SHMT2, SNRPA, TEX30 | View in SCUBA |
About the gene
| Synonyms | FLJ10036, KNTC1AP |
|---|---|
| Chromosome | 15: 66504959-66550130 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Cell cycle, Cell division, Mitosis |
Function
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.