HINT2 — Histidine triad nucleotide binding protein 2
HINT2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HINT2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Mitochondrial Metabolism Mitochondrial & OxPhos | CYC1, ELAVL1, PRDX3, RNPS1, SHMT2, SNRPA, TEX30, ZWILCH | View in SCUBA |
| Gamma-delta T cells | Mitochondrial OxPhos Mitochondrial & OxPhos | ADSL, AP1S1, CD151, COMTD1, COX5A, DDT, DNPH1, DUSP23 +20 more | |
| Innate lymphoid cells | Oxidative Phosphorylation Mitochondrial & OxPhos | APEX1, ATP5F1A, CCNC, COA3, DMAC1, ESD, HDAC2, LAMTOR1 +15 more | View in SCUBA |
| Mucosal-associated invariant T cell | ER & Mitochondrial Assembly Protein processing & ER | ANAPC11, ARRDC1, ATP5MC1, COA3, CSTB, DECR1, GSTK1, MRPS26 +9 more |
About the gene
| Chromosome | 9: 35812960-35815354 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase |
| Biological process | Apoptosis, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis |
Function
Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2. Hydrolyzes adenosine 5'-O- p-nitrophenylphosphoramidate (AMP-pNA). Hydrolyzes fluorogenic purine nucleoside tryptamine phosphoramidates in vitro. May be involved in steroid biosynthesis. May play a role in apoptosis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.