Mitochondrial Metabolism
Gene co-expression module in CD8⁺ T cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 4 of 9 genes have a known function matching the annotation |
Why this annotation
This small, coherent module contains CYC1 (cytochrome c1, Complex III), PRDX3 (mitochondrial peroxiredoxin), HINT2 (mitochondrial histidine triad nucleotide-binding protein), and SHMT2 (mitochondrial serine hydroxymethyltransferase) — all mitochondrial. ELAVL1 is an RNA-binding protein (HuR), SNRPA and RNPS1 are splicing factors, TEX30 is a putative RNA processing factor, and ZWILCH is a kinetochore component. The mitochondrial genes are core members, but the module also contains RNA processing genes. Given its neighborhood context (neighbor to M10 which is a clear OxPhos module), this module likely represents a complementary housekeeping mitochondrial metabolic program with co-varying RNA processing activity. The mitochondrial theme is the strongest signal.
Genes
CYC1, ELAVL1, HINT2, PRDX3, RNPS1, SHMT2, SNRPA, TEX30, ZWILCH
Most correlated modules
- General Housekeeping · correlation 0.96
- Cellular Housekeeping · correlation 0.96
- Replication Licensing · correlation 0.95
- Mitochondrial Housekeeping · correlation 0.95
- Glycolysis Program · correlation 0.95
- Cellular Housekeeping · correlation 0.95
- Mitochondrial ETC/OxPhos · correlation 0.94
- Rho GTPase Cytoskeletal · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.