RNPS1 — RNA binding protein with serine rich domain 1
RNPS1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RNPS1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Vesicular trafficking Housekeeping | ACSL4, ARL8B, BLOC1S2, C3orf38, DTX3L, EFCAB14, GGA2, HMGXB3 +17 more | View in SCUBA |
| CD8⁺ T cells | Mitochondrial Metabolism Mitochondrial & OxPhos | CYC1, ELAVL1, HINT2, PRDX3, SHMT2, SNRPA, TEX30, ZWILCH | View in SCUBA |
| Gamma-delta T cells | mRNA Splicing RNA processing & translation | ARHGDIA, DDX27, DDX59, EIF2AK1, EWSR1, FBXL5, GNL1, GTF2F1 +14 more | |
| Innate lymphoid cells | Endosomal Trafficking Signaling Immune regulation | ARF1, CCDC85B, CKLF, COMMD8, FAM50A, GDE1, HAX1, IL27RA +16 more | View in SCUBA |
| Macrophages | mRNA Splicing Processing Housekeeping | AP3D1, BAZ1B, CCDC47, CHTOP, CTCF, EIF1AX, EIF3A, HDLBP +29 more | View in SCUBA |
About the gene
| Chromosome | 16: 2253116-2268397 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins, Transporters |
| Molecular function | RNA-binding |
| Biological process | mRNA processing, mRNA splicing, Nonsense-mediated mRNA decay |
Function
Part of pre- and post-splicing multiprotein mRNP complexes. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Enhances the formation of the ATP-dependent A complex of the spliceosome. Involved in both constitutive splicing and, in association with SRP54 and TRA2B/SFRS10, in distinctive modulation of alternative splicing in a substrate- dependent manner. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Participates in mRNA 3'-end cleavage. Involved in UPF2-dependent nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Also mediates increase of mRNA abundance and translational efficiency. Binds spliced mRNA 20- 25 nt upstream of exon-exon junctions.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.