SNRPA — Small nuclear ribonucleoprotein polypeptide A
SNRPA belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SNRPA's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Mitochondrial Metabolism Mitochondrial & OxPhos | CYC1, ELAVL1, HINT2, PRDX3, RNPS1, SHMT2, TEX30, ZWILCH | View in SCUBA |
| Gamma-delta T cells | Basal Cell Maintenance Housekeeping | ARHGDIB, CYB561D2, DNAJC8, GPAA1, INO80E, LMF2, MIF4GD, OTUB1 +9 more | |
| Innate lymphoid cells | ILC Transcription Factor Program Differentiation | APP, DCTN2, DEF6, GRAMD1A, GRHPR, HSD17B12, HSPB1, ILK +11 more | View in SCUBA |
About the gene
| Synonyms | Mud1, U1-A, U1A |
|---|---|
| Chromosome | 19: 40750637-40765389 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Molecular function | Ribonucleoprotein, RNA-binding |
| Biological process | mRNA processing, mRNA splicing |
Function
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.